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1072-專題演講-1080306-麥德倫(中研院基因體中心)

演講活動
張貼人:李明芳公告日期:2019-01-09
 
Time3/6/2019 (Wed.) 14:20~16:20
SpeakerProf.麥德倫(Te-Lun Mai)
Genomics Research Center, Academia Sinica
TitleAnalysis of A-to-I RNA Editing: Evolution and Adaptation
AbstractAdenosine-to-inosine (A-to-I) RNA editing is a widely observed co-/post-transcriptional mechanism in metazoans, which leads A-to-G changes between the RNA products and the corresponding genomic sequences. However, the evolutionary history and functional interrogation of this mechanism remains largely unexplored. In this talk, I will present our recent results that show evolutionary aspects of A-to-I RNA editome across metazoan species, which provide unprecedented evidence on how this editing gradually expands its territory and increases its influence along the history of evolution [1]. In addition, by integrating genomic and transcriptomic sequencing data, our results reveal the relationship between nonsynonymous RNA editing and existing missense variants. This finding suggests a new insight of A-to-I RNA editing to be served as compensation roles in the aid to the tolerance of existing A/G missense variants in the human population, and attracts attention to this mechanism in pathogenomics studies in disease-associated genes
PlaceB102, Gongquan Campuses, NTNU

 
最後修改時間:2019-02-23 AM 10:52

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單位簡介

本系的重點研究領域包括:凝態物理、光電與奈米科學、高能與粒子物理、軟凝態物理與生物物理、原分子光學物理、及物理科學教育等。本系前身為臺灣省立師範學院理化系物理組,成立於民國三十五年(1946年)本校創校之始。民國五十一年(1962年)本系獨立成系,民國六十三年(1974年)成立物理研究所碩士班,民國八十年(1991年)成立研究所博士班。長久以來,本系肩負著培育臺灣中等學校物理科師資的重任,但也不忘在物理學術研究上求新求進步。至今本系培育出的學術人才已有一位中研院院士及近百位中研院研究員及大學教授,各行各業的高科技人材更是不勝枚舉。民國八十三年師資培育法改制後,本系已升級為尖端學術研究、科技應用研發、及中學師資培育三者齊備的系所。

  • 國立臺灣師範大學物理系系友會
  • 系友會線上小額捐款
  • 徐有庠盃-臺灣青年學生物理辯論競賽
  • 國際物理奧林匹亞競賽
  • BOSON CLUB
  • 公用場地與儀器設施預約系統
  • 學生實習專區
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